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| G6PD Newborn Screen Test |
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| Screens newborns for G6PD deficiency, preventing anemia or jaundice triggered by certain foods or drugs | ||
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Synonym | G-6-PD Newborn Test |
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Test Code | CHEM250045 |
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Test Type | Hematology |
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Pre-Test Condition | No special |
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Report Availability | 1–2 D(s) |
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# Test(s) | 1 |
| Test details | Sample Report |
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| G6PD Newborn Screen Test |
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| Synonym | G-6-PD Newborn Test | |
| Test Code | CHEM250045 | |
 | Test Category | ||
| Pre-Test Condition | No special | |
 | Medical History | Share & see Updates | |
| Report Availability | 1–2 D(s) | |
 | Specimen/Sample | Refer Updates | |
 | Stability @21-26 deg. C | 24 H(s) | |
 | Stability @ 2-8 deg. C | 48 H(s) | |
 | Stability @ Frozen | Not frozen | |
| # Test(s) | 1 | |
 | Processing Method | Spectrophotometry | |
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Overview: G6PD Newborn Screen Test
Introduction: The G6PD Newborn Screen Test screens newborns for G6PD deficiency, preventing anemia or jaundice triggered by certain foods or drugs. Following 2023 AAP guidelines, it uses spectrophotometry for high sensitivity, aiding in newborn screening. This test is critical for early detection and improving outcomes in hematology for newborns. Other Names: G6PD Newborn Assay, Neonatal G6PD Test. FDA Status: Laboratory-developed test (LDT), meeting hematology standards for diagnostic accuracy. Historical Milestone: G6PD newborn screening began in the 1970s in high-risk populations. Spectrophotometry improved in the 1990s, enhancing screening accuracy. Purpose: Screens for G6PD deficiency, prevents complications, and monitors enzyme levels in newborns. Test Parameters: 1. Glucose-6-Phosphate Dehydrogenase Pretest Condition: No fasting required. Collect dried blood spots within 24-48 hours of birth. Report family history of G6PD deficiency. Specimen: 3-5 dried blood spots (DBS card). Transport in a biohazard bag within 24 hours. Sample Stability at Room Temperature: 24 hours Sample Stability at Refrigeration: 48 hours Sample Stability at Frozen: Not frozen Medical History: Document family history of G6PD deficiency or neonatal jaundice. Include any known triggers. Consent: Written parental consent required, detailing the tests purpose, screening implications, and potential need for follow-up. Procedural Considerations: Uses spectrophotometry to measure G6PD enzyme activity in dried blood spots. Results are available in 1-2 days, enabling rapid clinical decisions. Factors Affecting Result Accuracy: Improper sample collection or storage can affect results. Hemolysis may reduce accuracy. Clinical Significance: Low G6PD activity suggests deficiency, prompting trigger avoidance. Normal results may require confirmatory testing. Specialist Consultation: Consult a pediatrician or hematologist for result interpretation. Additional Supporting Tests: G6PD quantitative test, CBC, or genetic testing to confirm deficiency. Test Limitations: False negatives may occur in newborns. Results require clinical correlation. References: AAP Newborn Screening Guidelines, 2023; Pediatrics, Kaplan M, 2022. |