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| HLA-DR Flow Cytometry Test |
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| Detects HLA DR markers to diagnose leukemia or lymphoma, causing fever or weight loss | ||
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Synonym | HLA DR Flow Test |
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Test Code | CHEM250039 |
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Test Type | Hematology |
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Pre-Test Condition | No special |
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Report Availability | 1–2 D(s) |
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# Test(s) | 1 |
| Test details | Sample Report |
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| HLA-DR Flow Cytometry Test |
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| Synonym | HLA DR Flow Test | |
| Test Code | CHEM250039 | |
 | Test Category | ||
| Pre-Test Condition | No special | |
 | Medical History | Share & see Updates | |
| Report Availability | 1–2 D(s) | |
 | Specimen/Sample | Refer Updates | |
 | Stability @21-26 deg. C | 24 H(s) | |
 | Stability @ 2-8 deg. C | 48 H(s) | |
 | Stability @ Frozen | Not frozen | |
| # Test(s) | 1 | |
 | Processing Method | Flow Cytometry | |
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Overview: HLA-DR Flow Cytometry Test
Introduction: The HLA-DR Flow Cytometry Test detects HLA-DR markers to diagnose leukemia or lymphoma, causing fever or weight loss. Following 2023 ASH guidelines, it uses flow cytometry for high specificity, aiding in cancer screening. This test is critical for guiding diagnosis, treatment, and improving outcomes in hematology for patients with suspected hematologic malignancies. Other Names: HLA-DR Flow Assay, MHC Class II Test. FDA Status: Laboratory-developed test (LDT), meeting hematology standards for diagnostic accuracy. Historical Milestone: HLA-DR testing began in the 1980s with leukemia research. Flow cytometry emerged in the 1990s, and standardized panels improved accuracy by the 2000s. Purpose: Diagnoses leukemia or lymphoma, guides treatment, and monitors HLA-DR markers in patients with fever or weight loss. Test Parameters: 1. HLA-DR Pretest Condition: No fasting required. Collect whole blood or bone marrow at any time. Report symptoms like fever or weight loss, and list medications. Specimen: 2-5 mL whole blood (EDTA) or 2-5 mL bone marrow (EDTA). Transport in a biohazard bag within 24 hours. Sample Stability at Room Temperature: 24 hours Sample Stability at Refrigeration: 48 hours Sample Stability at Frozen: Not frozen Medical History: Document fever, weight loss, or history of leukemia/lymphoma. Include current medications, especially chemotherapeutics. Consent: Written consent required, detailing the tests purpose, diagnostic implications, and potential need for cancer therapy. Procedural Considerations: Uses flow cytometry to detect HLA-DR markers. Results are available in 1-2 days, enabling rapid clinical decisions. Factors Affecting Result Accuracy: Poor sample quality or low cell yield can affect results. Non-malignant conditions may express HLA-DR. Clinical Significance: Positive HLA-DR expression suggests leukemia or lymphoma, prompting treatment. Negative results may require additional marker testing. Specialist Consultation: Consult a hematologist or oncologist for result interpretation. Additional Supporting Tests: Bone marrow biopsy, other flow cytometry markers, or PET scan to confirm leukemia/lymphoma. Test Limitations: Non-specific expression may occur in non-malignant conditions. Results require clinical correlation. References: ASH Leukemia Guidelines, 2023; Blood, Arber DA, 2022. |