Overview: Mean Platelet Volume Test
Introduction: The Mean Platelet Volume Test measures MPV to diagnose platelet disorders, causing bleeding or clotting issues. Following 2023 ASH guidelines, it uses biochemical methods for high specificity, supporting hematological screening. This test is critical for guiding diagnosis, treatment planning, and improving outcomes in hematology for patients with suspected thrombocytopenia or thrombocytosis.

Other Names: MPV Assay, Platelet Volume Test.

FDA Status: Laboratory-developed test (LDT), meeting hematology standards for diagnostic accuracy.

Historical Milestone: MPV testing began in the 1970s with hematology research. Automated analyzers improved in the 2000s, enhancing diagnostic precision.

Purpose: Measures MPV to diagnose platelet disorders, guides treatment, and evaluates patients with bleeding or clotting issues.

Test Parameters: 1. Mean Platelet Volume

Pretest Condition: No fasting required. Collect whole blood. Report history of bleeding, clotting issues, or platelet disorders.

Specimen: Whole Blood (EDTA, 2-5 mL). Transport in a biohazard container.

Sample Stability at Room Temperature: 24 hours

Sample Stability at Refrigeration: 48 hours

Sample Stability at Frozen: Not frozen

Medical History: Document bleeding, clotting issues, bruising, or family history of platelet disorders. Include current medications, especially anticoagulants.

Consent: Written consent required, detailing the tests purpose, platelet disorder implications, and risks of blood collection.

Procedural Considerations: Uses biochemical methods (e.g., automated hematology analyzer) to measure MPV in whole blood. Results are available in 1-2 days, supporting rapid clinical decisions. Performed in laboratories, often for platelet disorder diagnosis.

Factors Affecting Result Accuracy: Hemolysis, improper sample storage, or low sample volume can affect results. Analyzer calibration errors may reduce accuracy.

Clinical Significance: Abnormal MPV suggests platelet disorders (e.g., thrombocytopenia), guiding treatment (e.g., platelet transfusion). Normal levels may require further hematological testing.

Specialist Consultation: Consult a hematologist for result interpretation and treatment planning.

Additional Supporting Tests: Platelet count, bleeding time, or bone marrow biopsy to confirm platelet disorder diagnosis.

Test Limitations: Not specific to one platelet disorder; clinical correlation is needed. Sample quality affects accuracy.

References: ASH Platelet Guidelines, 2023; Blood, George JN, 2022.