Overview: Platelet Count Test
Introduction: The Platelet Count Test measures platelet count to diagnose bleeding or clotting disorders, causing bruising. Aligned with 2023 ASH guidelines, it uses hematological methods for high specificity, supporting blood disorder screening. This test is critical for guiding diagnosis, treatment planning, and improving outcomes in hematology for patients with suspected thrombocytopenia or thrombocytosis.

Other Names: Platelet Count Assay, PLT Test.

FDA Status: Laboratory-developed test (LDT), meeting hematology standards for diagnostic accuracy.

Historical Milestone: Platelet counting began in the 1950s with automated hematology analyzers. Methods improved in the 2000s, enhancing diagnostic precision.

Purpose: Measures platelet count to diagnose bleeding or clotting disorders, guides treatment, and evaluates patients with bruising.

Test Parameters: 1. Platelet Count

Pretest Condition: No fasting required. Collect whole blood. Report history of bruising, bleeding, or clotting symptoms.

Specimen: Whole Blood (EDTA, 2-5 mL). Transport in a biohazard container.

Sample Stability at Room Temperature: 24 hours

Sample Stability at Refrigeration: 48 hours

Sample Stability at Frozen: Not frozen

Medical History: Document bruising, bleeding, or family history of blood disorders. Include current medications, especially antiplatelet drugs.

Consent: Written consent required, detailing the tests purpose, bleeding/clotting disorder implications, and risks of sample collection.

Procedural Considerations: Uses automated hematology analyzers to measure platelet count. Results are available in 1-2 days, supporting clinical decisions. Performed in laboratories, often for blood disorder diagnosis.

Factors Affecting Result Accuracy: Improper sample storage or clotting can affect results. Medications like aspirin may reduce platelet count.

Clinical Significance: Low platelet count confirms thrombocytopenia, guiding transfusions or therapy. High counts may indicate thrombocytosis, requiring further evaluation.

Specialist Consultation: Consult a hematologist for result interpretation and treatment planning.

Additional Supporting Tests: Peripheral smear, bone marrow biopsy, or coagulation tests to confirm bleeding/clotting disorder diagnosis.

Test Limitations: Non-specific for certain blood disorders; clinical correlation is needed. Sample quality affects sensitivity.

References: ASH Thrombocytopenia Guidelines, 2023; Blood, George JN, 2022.