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**Overview**: **Allergy 107 Allergens LIA Profile****Introduction**: The Allergy 107 Allergens LIA Profile is a diagnostic tool designed to conduct comprehensive allergy screening using serum samples. Associated with allergic disorders like asthma, eczema, and anaphylaxis, these conditions present with itching, respiratory distress, and severe complications if untreated, particularly in individuals with environmental or food exposures. Per the 2023 American Academy of Allergy, Asthma & Immunology guidelines, the test employs allergology with line immunoassay technology, delivering detailed allergen identification over 1-2 days with high sensitivity and specificity, making it a valuable tool for allergy screening in clinical settings. This diagnostic falls under allergy screening and targets individuals with allergic symptoms, addressing the challenge of accurate allergen classification to guide avoidance or immunotherapy. With morbidity rates elevated due to underdiagnosis, the test supports public health efforts by enabling precise identification, facilitating management, and reducing complications. Its serum-based approach ensures reliable detection.**Other Names**: Allergy 107 LIA Pfl.**FDA Status**: FDA approved, CLIA certified for allergology, compliant with 2025 standards.**Historical Milestone**: Introduced in the 2000s by various allergy labs, this test advanced allergy diagnostics by standardizing multi-allergen analysis.**Purpose**: The test screens for 107 allergens including total IgE and grass pollen to guide allergy assessment, assess immune response, and inform treatment and prevention strategies.**Test Parameters**: 1. Total IgE, 2. Grass Pollen (Bermuda), 3. Grass Pollen (Timothy), 4. Tree Pollen (Eucalyptus), 5. Tree Pollen (Acacia), 6. Weed Pollen (Ragweed), 7. Weed Pollen (Mugwort), 8. Dust Mite (D. pteronyssinus), 9. Dust Mite (D. farinae), 10. Cat Dander, 11. Dog Dander, 12. Cockroach, 13. Mold (Alternaria), 14. Mold (Aspergillus), 15. Mold (Penicillium), 16. Milk, 17. Egg White, 18. Egg Yolk, 19. Peanut, 20. Soybean, 21. Wheat, 22. Rice, 23. Corn, 24. Fish (Cod), 25. Shrimp, 26. Crab, 27. Lobster, 28. Chicken, 29. Beef, 30. Pork, 31. Almond, 32. Cashew, 33. Hazelnut, 34. Walnut, 35. Sesame Seed, 36. Mustard, 37. Tomato, 38. Potato, 39. Carrot, 40. Apple, 41. Banana, 42. Orange, 43. Mango, 44. Strawberry, 45. Kiwi, 46. Peach, 47. Melon, 48. Lentil, 49. Chickpea, 50. Pea, 51. Kidney Bean, 52. Green Bean, 53. Coconut, 54. Celery, 55. Garlic, 56. Onion, 57. Cucumber, 58. Spinach, 59. Cabbage, 60. Mushroom, 61. Yeast, 62. Honey, 63. Chocolate, 64. Coffee, 65. Tea, 66. Pepper, 67. Sunflower Seed, 68. Olive, 69. Soy Lecithin, 70. Latex, 71. Cotton, 72. Wool, 73. Feathers, 74. House Dust, 75. Mosquito, 76. Horse Dander, 77. Rabbit Dander, 78. Guinea Pig Dander, 79. Parrot Feathers, 80. Pine Pollen, 81. Oak Pollen, 82. Birch Pollen, 83. Cedar Pollen, 84. Johnson Grass, 85. Bahia Grass, 86. Rye Grass, 87. Velvet Grass, 88. Common Pigweed, 89. Goosefoot, 90. Candida albicans.**Pretest Condition**: No fasting required; patients should avoid antihistamines and report itching, respiratory distress, or recent allergen exposure.**Specimen**: 3 mL serum in 1 SST, transported within specified times to maintain sample viability.**Sample Stability at Room Temperature**: 8 hours (Serum) with proper handling to preserve analyte integrity, ensuring reliable test performance.**Sample Stability at Refrigeration**: 7 days (Serum) at 2-8 degrees Celsius, suitable for short-term storage before laboratory processing, though immediate testing is preferred.**Sample Stability at Frozen**: 6 months (Serum) at -20 degrees Celsius, allowing long-term storage for retesting, though freezing may affect some analytes.**Medical History**: Patients should provide details on itching, respiratory distress, prior allergic reactions, or family history of allergies, as well as any recent trauma or treatments.**Consent**: Written informed consent is required, detailing the test's purpose, potential risks of untreated allergies including anaphylaxis, benefits of early detection, and minimal discomfort from sample collection.**Procedural Considerations**: The test involves sample processing using line immunoassay and interpret results within 1-2 days using provided controls.**Factors Affecting Result Accuracy**: Delays beyond stability periods, improper storage conditions, cross-contamination with other samples, or recent antihistamine use can affect results. Correlation with clinical evaluation or skin testing is recommended to confirm findings.**Clinical Significance**: Abnormal results indicate possible allergic sensitivities, necessitating further investigation like specialist consultation or additional testing. Normal results may require follow-up if symptoms persist, especially in early sensitization stages.**Specialist Consultation**: General practitioners or specialists in allergology or immunology should be consulted for case management, treatment planning, and coordination with health programs.**Additional Supporting Tests**: Skin prick test, specific IgE levels, or challenge testing for confirmation.**Test Limitations**: The test may produce false negatives in early sensitization or false positives in cross-reactive conditions, requiring a comprehensive diagnostic approach that includes clinical correlation.**References**: AAAAI Guidelines 2023, Journal of Allergy and Clinical Immunology 2024, Allergology 2025. |
