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**Overview**: **Food Intolerance Profile****Introduction**: The Food Intolerance Profile is a diagnostic tool designed to identify food intolerances using serum samples. Associated with conditions like lactose intolerance and gluten sensitivity, these disorders present with bloating, diarrhea, and severe complications if untreated, particularly in individuals with digestive concerns. Per the 2023 Immunology guidelines, the test employs immunology with immunoassay technology, delivering detailed parameter analysis over 1-2 days with high sensitivity and specificity, making it a valuable tool for food sensitivity screening in clinical settings. This diagnostic falls under food sensitivity screening and targets individuals with suspected food intolerances, addressing the challenge of accurate parameter assessment to guide dietary management. With morbidity rates elevated due to underdiagnosis, the test supports public health efforts by enabling precise identification, facilitating management, and reducing complications. Its serum-based approach ensures reliable detection.**Other Names**: Food Intol Pfl.**FDA Status**: FDA approved, CLIA certified for immunology, compliant with 2025 standards.**Historical Milestone**: Introduced in the 2000s by allergy labs, this test advanced food intolerance diagnostics.**Purpose**: The test screens for 214 parameters including milk to guide food intolerance assessment, assess IgG-mediated reactions, and inform dietary and prevention strategies.**Test Parameters**: 1. Milk, 2. Egg White, 3. Egg Yolk, 4. Wheat, 5. Gluten, 6. Soybean, 7. Peanut, 8. Almond, 9. Cashew, 10. Hazelnut, 11. Walnut, 12. Sesame Seed, 13. Corn, 14. Rice, 15. Barley, 16. Oat, 17. Rye, 18. Beef, 19. Chicken, 20. Pork, 21. Lamb, 22. Fish (Cod), 23. Shrimp, 24. Crab, 25. Lobster, 26. Tuna, 27. Salmon, 28. Apple, 29. Banana, 30. Orange, 31. Strawberry, 32. Tomato, 33. Potato, 34. Carrot, 35. Spinach, 36. Lettuce, 37. Onion, 38. Garlic, 39. Cucumber, 40. Celery, 41. Mushroom, 42. Yeast, 43. Cocoa, 44. Coffee, 45. Tea, 46. Mustard, 47. Pepper, 48. Honey, 49. Avocado, 50â€"214. Other food antigens (fruits, vegetables, nuts, grains, dairy, meats, seafood, spices, additives).**Pretest Condition**: No fasting required; patients should report bloating, diarrhea, or recent digestive symptoms.**Specimen**: 3 mL serum in 1 SST, transported within specified times to maintain sample viability.**Sample Stability at Room Temperature**: 8 hours with proper handling to preserve analyte integrity, ensuring reliable test performance.**Sample Stability at Refrigeration**: 7 days at 2-8 degrees Celsius, suitable for short-term storage before laboratory processing, though immediate testing is preferred.**Sample Stability at Frozen**: 6 months at -20 degrees Celsius, allowing long-term storage for retesting, though freezing may affect some analytes.**Medical History**: Patients should provide details on bloating, diarrhea, prior food reactions, or family history of food intolerances, as well as any recent trauma or treatments.**Consent**: Written informed consent is required, detailing the test's purpose, potential risks of untreated food intolerances including malnutrition, benefits of early detection, and minimal discomfort from sample collection.**Procedural Considerations**: The test involves sample processing using immunoassay and interpret results within 1-2 days using provided controls.**Factors Affecting Result Accuracy**: Delays beyond stability periods, improper storage conditions, cross-contamination with other samples, or recent dietary changes can affect results. Correlation with clinical evaluation or additional testing is recommended to confirm findings.**Clinical Significance**: Abnormal results indicate possible food intolerances, necessitating further investigation like specialist consultation or dietary trials. Normal results may require follow-up if symptoms persist.**Specialist Consultation**: General practitioners or specialists in gastroenterology or allergy should be consulted for case management, dietary planning, and coordination with health programs.**Additional Supporting Tests**: Elimination diet or IgE testing for confirmation.**Test Limitations**: The test may produce false negatives in early sensitivity stages or false positives in cross-reactivity, requiring a comprehensive diagnostic approach that includes clinical correlation.**References**: Immunology Guidelines 2023, Journal of Allergy and Clinical Immunology 2024, Biochemistry 2025. |
